Having personally reviewed a total of 12 venues, I can confidently recommend the top-notch establishments that serve the best seafood in Greenville, SC. Being a passionate seafood enthusiast myself, I have scoured the city to compile this comprehensive guide to satisfy even the most discerning palates.

Whether you're a local in search of a new favorite seafood joint or a visitor looking to indulge in the South's finest catches, this article has got you covered. So, join me on a culinary journey as we explore the unparalleled flavors and fresh seafood offerings that Greenville, SC has to offer.


The Seafood Spot

The Seafood Spot
🗺️ 219 W Antrim Dr C, Greenville, SC 29607
☎️ 864-520-2010
🌐 Website
Sunday: Closed
Monday: Closed
Tuesday: Closed
Wednesday: 4–8 PM
Thursday: 4–8 PM
Friday: 12–9 PM
Saturday: 12–9 PM
Highlights
Legit fried fish
Owners treat you
Clean and spacious
Garlic sauce amazing
Feel like family

Let me start by saying, holy shellfish, this place is where it's at for seafood lovers in Greenville! From the moment I walked in, I could tell this was the real deal.

First off, let's talk about their legit fried fish. Crispy on the outside, tender on the inside, and perfectly seasoned, it was a taste sensation that had my taste buds doing a happy dance. But it wasn't just the seafood that impressed me, it was also the owners and staff who truly made the experience memorable.

The owners at The Seafood Spot really know how to treat their customers. From the moment I walked in, I was greeted with a warm smile and a genuine welcome. They made me feel like family, which is a rare find in a restaurant these days. It's clear that they have a passion for their business and take pride in providing an excellent dining experience to everyone who walks through their doors.

Speaking of doors, I was pleasantly surprised by how clean and spacious the restaurant was. It felt comfortable and inviting, perfect for enjoying a seafood feast with friends or family. And let me tell you, their garlic sauce is out of this world. It was so amazing that I couldn't help but slather it on every bite. It added the perfect burst of flavor to an already fantastic meal.

So, if you're looking for the best seafood in Greenville SC, look no further than The Seafood Spot. It's a playful yet professional establishment that will have you coming back for more. Trust me, your taste buds will thank you.

You might also want to check out the best seafood in Anderson SC.

Bimini's Oyster Bar and Seafood Cafe

Bimini's Oyster Bar and Seafood Cafe
🗺️ 100 Villa Rd, Greenville, SC 29615
☎️ 864-242-2497
🌐 Website
Sunday: 11:30 AM–9 PM
Monday: 11:30 AM–9 PM
Tuesday: 11:30 AM–9 PM
Wednesday: 11:30 AM–9 PM
Thursday: 11:30 AM–9 PM
Friday: 11:30 AM–10 PM
Saturday: 11:30 AM–10 PM
Highlights
Shorter-than-expected wait
Attentive and quick service
Delicious food
Live entertainment
Vibrant atmosphere

From the moment I stepped into Bimini's Oyster Bar and Seafood Cafe, I knew I was in for a treat. The vibrant atmosphere, complete with live entertainment, immediately set the stage for a memorable dining experience.

One highlight of my visit was the shorter-than-expected wait. As a seafood enthusiast, I eagerly anticipated tasting the dishes prepared by the talented chefs at Bimini's. Thankfully, the wait was brief, allowing me to dive right into the seafood extravaganza.

The service at Bimini's was truly outstanding. The staff was not only attentive but also quick in their service, ensuring that each customer received their orders promptly. From providing recommendations to keeping our glasses filled, the level of professionalism displayed by the staff truly added to the overall dining experience.

Now, let's talk about the food. Oh boy, did Bimini's deliver! From succulent oysters to perfectly cooked shrimp, every dish was a masterpiece. The flavors were exquisite, with each bite bursting with freshness. The chefs clearly know their craft and excel in creating seafood dishes that are both delicious and visually appealing.

Overall, Bimini's Oyster Bar and Seafood Cafe deserves its place among the best seafood establishments in Greenville SC. It offers a playful yet professional ambiance, attentive service, and most importantly, a delicious array of seafood dishes. Whether you're a seafood lover or simply looking for a memorable dining experience, Bimini's is a must-visit destination.

You might also want to check out the best seafood in Asheville NC.

The Jones Oyster Co.

The Jones Oyster Co.
🗺️ 22 E Court St, Greenville, SC 29601
☎️ 864-549-0301
🌐 Website
Sunday: Closed
Monday: Closed
Tuesday: 11 AM–9 PM
Wednesday: 11 AM–9 PM
Thursday: 11 AM–9 PM
Friday: 11 AM–10 PM
Saturday: 11 AM–10 PM
Highlights
Excellent customer service
High quality seafood
Fresh oysters
Chef selection of oysters
Variety of oyster flavors

Let me start by saying that the customer service at The Jones Oyster Co. is truly fantastic. From the moment I walked in, the staff was warm, friendly, and attentive. They made me feel like a valued customer, and that's always a great start to any dining experience.

Now, let's talk about the star of the show - the seafood. The Jones Oyster Co. offers some of the highest quality seafood in Greenville SC. Every bite was a testament to the fresh and delicious flavors that only the ocean can provide. But what really made this place stand out were the oysters.

The oysters at The Jones Oyster Co. were simply outstanding. They were so fresh that I could practically taste the ocean in every bite. The chef selection of oysters was a great way to experience different flavors and textures. From briny to sweet, each oyster had its own distinct taste that left me wanting more.

I must commend the variety of oyster flavors available. It was like a journey through the ocean, with each oyster offering a unique taste experience. Whether you prefer them raw, grilled, or fried, The Jones Oyster Co. has something to satisfy every palate.

In conclusion, The Jones Oyster Co. is a must-visit for any seafood lover in Greenville SC. With excellent customer service, high quality seafood, and a delightful variety of oyster flavors, this place truly stands out as one of the best seafood restaurants in town. So, grab a seat, indulge in some fresh oysters, and let your taste buds embark on a mouthwatering journey.

You might also want to check out the best seafood market in Charlotte.

Shuckin' Shack Oyster Bar

Shuckin' Shack Oyster Bar
🗺️ 3620 Pelham Rd #4, Greenville, SC 29615
☎️ 864-335-8975
🌐 Website
Sunday: 11:30 AM–9 PM
Monday: 11:30 AM–9 PM
Tuesday: 11:30 AM–9 PM
Wednesday: 11:30 AM–9 PM
Thursday: 11:30 AM–9 PM
Friday: 11:30 AM–11 PM
Saturday: 11:30 AM–11 PM

I must say, Shuckin' Shack Oyster Bar is shuckin' amazing! The oysters were sensational, with the perfect balance of brininess and creaminess. And their crab legs? To die for, succulent and so flavorful! The cozy ambiance and friendly service added an extra zing to the overall experience. Definitely a must-visit spot for seafood lovers in Greenville SC.

You might also want to check out the best seafood in Athens GA.

Mr. Crisp

Mr. Crisp
🗺️ 1501 E North St Suite 102, Greenville, SC 29607
☎️ 864-549-8149
🌐 Website
Sunday: Closed
Monday: Closed
Tuesday: 5–9:30 PM
Wednesday: 5–9:30 PM
Thursday: 5–9:30 PM
Friday: 5–9:30 PM
Saturday: 5–9:30 PM

Mr. Crisp in Greenville SC is a hidden gem for seafood lovers! Their menu boasts an array of fresh and flavorful seafood options that are cooked to perfection. From their crispy fish tacos to their succulent shrimp po' boys, every bite will transport you to the beach. Don't forget to try their secret spicy shrimp sauce - it's a game-changer. Overall, Mr. Crisp is a must-visit spot for seafood enthusiasts in Greenville SC.

You might also want to check out the best seafood in Gatlinburg.

Coral Greenville

Coral Greenville
🗺️ 654 S Main St, Greenville, SC 29601
☎️ 864-619-0017
🌐 Website
Sunday: Closed
Monday: Closed
Tuesday: Closed
Wednesday: 4–9 PM
Thursday: 4–10 PM
Friday: 4–11 PM
Saturday: 4–11 PM

Coral Greenville in Greenville SC is a true hidden gem in the seafood scene. From the moment you step foot inside their vibrant and inviting restaurant, you know you're in for a treat. The menu boasts a wide variety of fresh, locally sourced seafood dishes that are sure to satisfy any seafood lover's cravings. The flavorful and expertly prepared dishes at Coral Greenville are a testament to their commitment to quality. With a playful yet professional atmosphere, this seafood haven is a must-visit for anyone seeking the best seafood in Greenville SC.

You might also want to check out the best seafood in Charlotte North Carolina.

Harbor Inn Cajun Seafood

Harbor Inn Cajun Seafood
🗺️ 321 Haywood Rd, Greenville, SC 29607
☎️ 864-286-9047
🌐 Website
Sunday: 11 AM–9 PM
Monday: Closed
Tuesday: 11 AM–9 PM
Wednesday: 11 AM–9 PM
Thursday: 11 AM–9 PM
Friday: 11 AM–10 PM
Saturday: 11 AM–10 PM

Harbor Inn Cajun Seafood in Greenville SC was a delightful surprise! Their catch of the day was absolutely off the hook and left me feeling shell-shocked in the best possible way. This playful yet professional spot is a must-visit for seafood lovers in the area.

You might also want to check out the best seafood buffet in Pigeon Forge.

Crab Du Jour Cajun Seafood & Bar

Crab Du Jour Cajun Seafood & Bar
🗺️ 1209 Woodruff Rd, Greenville, SC 29607
☎️ 864-438-1666
🌐 Website
Sunday: 11:30 AM–9 PM
Monday: Closed
Tuesday: 11:30 AM–10 PM
Wednesday: 11:30 AM–10 PM
Thursday: 11:30 AM–10 PM
Friday: 11:30 AM–11 PM
Saturday: 11:30 AM–11 PM

Crab Du Jour Cajun Seafood & Bar in Greenville SC is a seafood lover's dream come true. Their playful yet professional atmosphere creates a captivating dining experience. From their mouthwatering crab legs to their flavorful Cajun boils, every bite is an explosion of tantalizing flavors. Don't leave without trying their succulent shrimp and their crispy hush puppies. Trust me, seafood enthusiasts won't be disappointed at Crab Du Jour Cajun Seafood & Bar.

You might also want to check out the best seafood in Augusta GA.

Blockhouse Restaurant and Oyster Bar

Blockhouse Restaurant and Oyster Bar
🗺️ 1619 Augusta St, Greenville, SC 29605
☎️ 864-232-4280
🌐 Website
Sunday: 11 AM–10 PM
Monday: 12–10:30 PM
Tuesday: 11 AM–10:30 PM
Wednesday: 11 AM–10:30 PM
Thursday: 11 AM–10:30 PM
Friday: 11 AM–11 PM
Saturday: 11 AM–11 PM

Blockhouse Restaurant and Oyster Bar in Greenville SC is a hidden gem that offers an array of exquisite seafood dishes. From their succulent oysters to their perfectly grilled fish, every bite is a taste of culinary bliss. With a playful yet professional atmosphere, it's the ultimate seafood destination in Greenville SC.

You might also want to check out the best seafood in Pigeon Forge.

Red Lobster

Red Lobster
🗺️ 1940 Wade Hampton Blvd, Greenville, SC 29615
☎️ 864-268-1474
🌐 Website
Sunday: 11 AM–10 PM
Monday: 11 AM–10 PM
Tuesday: 11 AM–10 PM
Wednesday: 11 AM–10 PM
Thursday: 11 AM–10 PM
Friday: 11 AM–11 PM
Saturday: 11 AM–11 PM

Oh, Red Lobster, the mecca for seafood lovers in Greenville SC! With its playful yet professional atmosphere, I couldn't resist diving into their succulent lobster tails and flavorful shrimp scampi. The freshness and quality of the seafood here is undeniable – a must-try for any seafood enthusiast in town!

You might also want to check out the best seafood in Gatlinburg and Pigeon Forge.

Bonefish Grill

Bonefish Grill
🗺️ 1515 Woodruff Rd, Greenville, SC 29607
☎️ 864-297-5142
🌐 Website
Sunday: 11 AM–10 PM
Monday: 11 AM–10 PM
Tuesday: 11 AM–10 PM
Wednesday: 11 AM–10 PM
Thursday: 11 AM–10 PM
Friday: 11 AM–11 PM
Saturday: 11 AM–11 PM

Bonefish Grill in Greenville SC is a seafood lover's paradise! Their menu boasts a delightful array of flavorful dishes, from succulent crab cakes to perfectly grilled salmon. The playful and professional ambiance adds to the overall experience. Trust me, you won't be disappointed!

You might also want to check out the best seafood buffet in Charlotte NC.

Crab Du Jour Cajun Seafood & Bar - Cherrydale

Crab Du Jour Cajun Seafood & Bar - Cherrydale
🗺️ 3201 N Pleasantburg Dr, Greenville, SC 29609
☎️ 864-263-3193
🌐 Website
Sunday: 11:30 AM–10 PM
Monday: 11:30 AM–10 PM
Tuesday: 11:30 AM–10 PM
Wednesday: 11:30 AM–10 PM
Thursday: 11:30 AM–10 PM
Friday: 11:30 AM–11 PM
Saturday: 11:30 AM–11 PM

Crab Du Jour Cajun Seafood & Bar - Cherrydale in Greenville SC is a delightful treasure trove of flavorful and spicy Cajun seafood. The succulent crab legs and shrimp boils explode with a tantalizing combination of seasonings and spices. The playful yet professional atmosphere makes it a perfect spot to indulge in some exquisite seafood delights.

You might also want to check out the best seafood boil in Charlotte.

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Benjamin Marlowe

Ben is a passionate seafood enthusiast with a discerning palate and an insatiable curiosity for exploring the world's coastal culinary treasures. Born and raised on the shores of New England, Ben developed a deep appreciation for seafood from an early age, where the scent of the sea and the taste of fresh catches became an integral part of his life.